Description | (±)-Propionylcarnitine chloride (Propionyl-DL-carnitine chloride) is a mixture of short-chain acylcarnitines used as a dietary supplement for the study of chronic diabetes. |
In vivo | 在成年同龄雄性 C57BL/6 小鼠中,(±)-Propionylcarnitine chloride(2 mM/kg;口服灌胃;每天2 mM/kg,持续4周)能够增加小鼠血浆和尿液中的总肉碱浓度,但对小鼠骨骼肌中的肉碱含量没有影响。 |
Synonyms | Propionyl-DL-carnitine chloride |
molecular weight | 253.72 |
Molecular formula | C10H20ClNO4 |
CAS | 18828-58-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility | DMSO: 80 mg/mL (315.31 mM), Sonification is recommended. Methanol: 100 mg/mL (394.34 mM), Sonification is recommended. H2O: 8 mg/mL (31.53 mM), Sonification is recommended. |
References | 1. Palmieri L, et al. Protection of beta-thalassaemic erythrocytes from oxidative stress by propionyl carnitine. Int J Tissue React. 1994;16(3):121-9. 2. Tassani V, et al. Anaplerotic effect of propionyl carnitine in rat heart mitochondria. Biochem Biophys Res Commun. 1994 Mar 15;199(2):949-53. 3. Morand R, et al. Effect of carnitine, acetyl-, and propionylcarnitine supplementation on the body carnitine pool, skeletal muscle composition, and physical performance in mice. Eur J Nutr. 2014 Sep;53(6):1313-25. 4. Bertelli A, et al. Effect of propionyl carnitine on energy charge and adenine nucleotide content of cardiac endothelial cells during hypoxia. Int J Tissue React. 1991;13(1):37-40. |