| Description | Pheophorbide A is a photosensitizer used in in vivo photodynamic therapy (PDT).Phoophorbide A is a lymphatic vasoreactivator with antioxidant, anti-inflammatory, antitumor, and hypoglycemic activities.Phoophorbide A is used in research on diabetes and cancer. |
| In vitro | Pheophorbide A 显著抑制 Hep3B 细胞的生长，IC50值为1.5μM。Pa-PDT 处理细胞中细胞内 ROS 水平升高，当应用抗坏血酸时，细胞毒性作用可以逆转[2]。 |
| In vivo | 在雄性免疫正常的 C3H 小鼠( 6周龄,皮下接种 AT-84 细胞)、Pheophorbide a或( 10 mg/kg静脉注射( i.v.) 30 mg/kg腹腔注射；24 h后)显著抑制肿瘤生长达70 %[1]。 |
| molecular weight | 592.68 |
| Molecular formula | C35H36N4O5 |
| CAS | 15664-29-6 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 1 mg/mL (1.69 mM), Sonication is recommended. DMF: 1 mg/mL (1.69 mM), Sonication is recommended. DMSO:PBS(pH 7.2) (1:3): 0.25 mg/mL Methanol: < 1 mg/mL (Insoluble) |
| References | 1. Jihye Kim, et al. Pheophorbide a identified in an Eupatorium perfoliatum extract is a novel lymphatic vascular activator. Biomed Pharmacother. 2022 Mar;147:112664. 2. Tang PM, et al. Pheophorbide a, an active compound isolated from Scutellaria barbata, possesses photodynamic activities by inducing apoptosis in human hepatocellular carcinoma. Cancer Biol Ther. 2006 Sep;5(9):1111-6. 3. Ahn MY, et al. Pheophorbide a-mediated photodynamic therapy induces apoptotic cell death in murine oral squamous cell carcinoma in vitro and in vivo. Oncol Rep. 2012 Jun;27(6):1772-8. |