| Description | Monomethyl fumarate is a potent agonist of GPR109A . |
| In vitro | Monomethyl fumarate（25 μM；24小时处理）减轻了7β-OHC诱导的细胞毒性，包括细胞生长抑制、细胞活性降低、线粒体功能障碍以及细胞死亡诱导[3]。 |
| molecular weight | 130.1 |
| Molecular formula | C5H6O4 |
| CAS | 2756-87-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/mL (422.75 mM), Sonication is recommended. H2O: 8 mg/mL (61.49 mM), Sonication and heating to 60℃ are recommended. |
| References | 1. Tang H, et al. The psoriasis drug monomethylfumarate is a potent nicotinic acid receptor agonist. Biochem Biophys Res Commun. 2008 Oct 31;375(4):562-5. 2. Jiang D, et al. Monomethyl Fumarate Protects the Retina From Light-Induced Retinopathy. Invest Ophthalmol Vis Sci. 2019 Mar 1;60(4):1275-1285. 3. Sghaier R, et al. Dimethyl fumarate and monomethyl fumarate attenuate oxidative stress and mitochondrialalterations leading to oxiapoptophagy in 158N murine oligodendrocytes treated with 7β-hydroxycholesterol. J Steroid Biochem Mol Biol. 2019 Nov;194:105432. |