| Description | D-Glutamic acid ((R)-Glutamic acid), the enantiomer of L-glutamic acid, is widely used in medicine and food. |
| In vitro | 多种d-氨基酸，如D-丝氨酸、D-天冬氨酸（D-Asp）和D-谷氨酸（D-Glu），在包括人类在内的哺乳动物中广泛存在，现在被认为是它们的新型生理活性物质和/或生物标志物的候选物。D-[Asp/Glu]（4 mg/mL）抑制了IgE与花生的结合（75%），而D-Glu和D-Asp则无抑制作用。IgE对D-[Asp/Glu]具有特异性，并可能具备消除IgE或减少IgE与花生过敏原结合的潜力。 |
| In vivo | 目前，D-glutamic acid 作为神经传递和激素分泌的调节剂受到关注。它仅在哺乳动物体内被 D-aspartate oxidase 代谢。经过腹腔注射后，L-glutamic acid 通过 α-ketoglutarate 被分解，而 D-glutamic acid 转化为 n-pyrrolidone carboxylic acid。D-和 L-glutamic acid 的碳2在盲肠中被转化为甲基乙酸。大鼠肝脏和肾脏都能催化 D-glutamic acid 至 n-pyrrolidone carboxylic acid 的转换。 |
| Synonyms | (R)-Glutamic acid, D-谷氨酸 |
| molecular weight | 147.13 |
| Molecular formula | C5H9NO4 |
| CAS | 6893-26-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 10 mg/mL (67.97 mM), Sonication is recommended. |
| References | 1. Han H, et al. Changes in D-aspartic acid and D-glutamic acid levels in the tissues and physiological fluids of mice with various D-aspartate oxidase activities. J Pharm Biomed Anal. 2015 Dec 10;116:47-52. 2. Chung SY, et al. IgE binding to peanut allergens is inhibited by combined D-aspartic and D-glutamic acids. Food Chem. 2015 Jan 1;166:248-53. 3. Wilson W, et al. The metabolism of D- and L- glutamic acid in the rat. J Biol Chem. 1961 Feb;236:365-9. |