| Description | Levomenol ((-)-α-BISABOLOL) is a sesquiterpene alcohol that has been found in the essential oils of several aromatic plants, with exerts antioxidant, anti-inflammatory, and anti-apoptotic activities. |
| In vitro | (-)-α-bisabolol was able to activate a programmed cell death process in the promastigote stage of the parasite.?It causes phosphatidylserine externalization and membrane damage.?Moreover, it decreases the mitochondrial membrane potential and total ATP levels.?These results highlight the potential use of (-)-α-bisabolol against both L. amazonensis and L. infantum, and further studies should be undertaken to establish it as novel leishmanicidal therapeutic agents[1]. |
| In vivo | Levomenol inhibits the growth of L. amazonensis promastigotes and amastigotes (IC50s = 8.07 and 4.29 μg/ml, respectively). It also reduces the growth of L. infantum and L. donovani amastigotes (IC50s = 56.9 and 39.4 μM, respectively) with a cytotoxic concentration (CC50) value of greater than 1,000 μM in L929 cells[2]. |
| Synonyms | 没药醇, (-)-α-BISABOLOL, (-)-α-红没药醇 |
| molecular weight | 222.37 |
| Molecular formula | C15H26O |
| CAS | 23089-26-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 22.5 mg/mL (101.18 mM) |
| References | 1. Soumaya H , Ines S , López-Arencibia Atteneri, et al. Leishmanicidal activity of α-bisabolol from Tunisian chamomile essential oil[J]. Parasitology Research, 2018. 2. Corpas-López, Victoriano, Morillas-Márquez, Francisco, Navarro-Moll, M. Concepción, et al. (?)-α-Bisabolol, a Promising Oral Compound for the Treatment of Visceral Leishmaniasis[J]. Journal of Natural Products, 2015, 78(6):1202-1207. |