| Description | Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation, and anti-tumor effects. Hydroxycitric acid tripotassium hydrate(Potassium citrate monohydrate) (Potassium citrate monohydrate) is the major active ingredient of Garcinia cambogia and a derivative of citric acid. Hydroxycitric acid tripotassium hydrate(Potassium citrate monohydrate) competitively inhibits ATP citrate lyase with weight loss benefits. |
| In vitro | Hydroxycitric acid tripotassium 在ARPE19细胞和661W细胞中通过降低CoCl2诱导的HIF-1α蛋白表达发挥抑制作用。该化合物还能减少鸡肝细胞内脂质滴的积累，并加速能量代谢。Hydroxycitric acid tripotassium 通过提升抗氧化状态和线粒体功能，保护细胞免受内质网应激损伤。与对照组相比，Hydroxycitric acid tripotassium 在ARPE19细胞和661W细胞中展现出抑制HIF的效果，并能下调Hif1a及其下游基因的表达。 |
| In vivo | Hydroxycitric acid tripotassium 缓解了由草酸钙结晶引起的氧化应激。此化合物抑制了草酸钙诱导的炎症细胞因子，如MCP-1、IL-1β和IL-6的效应。此外，Hydroxycitric acid tripotassium 减轻了草酸钙晶体导致的肾小管损伤和细胞凋亡。Hydroxycitric acid tripotassium 的投给能够抑制动物体重增长和脂肪积累。Hydroxycitric acid tripotassium （100-200 mg/kg）的治疗能减少肾功能损害的标志物（血尿素氮和血清肌酐）。使用Hydroxycitric acid tripotassium 处理的小鼠（雄性C57BL/6J小鼠）中草酸钙晶体沉积显著减少。 |
| Synonyms | 柠檬酸钾一水合物, 三水合钾柠檬酸, Potassium citrate monohydrate |
| molecular weight | 324.41 |
| Molecular formula | C6H7K3O8 |
| CAS | 6100-05-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 2.49 mg/mL (10 mM) |
| References | 1. Liu X, et al. Hydroxycitric acid inhibits renal calcium oxalate deposition by reducing oxidative stress and inflammation. Curr Mol Med. 2020 Jan 3. 2. Ibuki M, et al. Therapeutic Effect of Garcinia cambogia Extract and Hydroxycitric Acid Inhibiting Hypoxia-Inducible Factor in a Murine Model of Age-Related Macular Degeneration. Int J Mol Sci. 2019 Oct 11;20(20). pii: E5049. 3. Han S, et al. Hydroxycitric Acid Tripotassium Inhibits Calcium Oxalate Crystal Formation in the Drosophila Melanogaster Model of Hyperoxaluria. Med Sci Monit. 2019 May 17;25:3662-3667. 4. Heymsfield SB, et al. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA. 1998 Nov 11;280(18):1596-600. |
Hydroxycitric acid tripotassium hydrate
CAS No.: 6100-05-6
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits stones formation and also i
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