| Description | Graveoline (2-(Benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-one) is an apoptosis and autophagy inducer in skin melanoma cancer cells |
| In vitro | MTT实验结果显示，对于A375细胞，随着graveoline浓度从最小到更高的逐渐增加，细胞活性逐步下降。当使用22.23 ± 0.79 μg/mL的graveoline处理时，细胞活性减少到50%[1]。 |
| Synonyms | 1-甲基-2- [3' ,4' - (亚甲二氧基)苯基] -4-喹诺酮, 2-(Benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-one, Foliosine |
| molecular weight | 279.29 |
| Molecular formula | C17H13NO3 |
| CAS | 485-61-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 5.2 mg/mL (18.62 mM) |
| References | 1. Ghosh S, Bishayee K, Khuda-Bukhsh AR. Graveoline isolated from ethanolic extract of Ruta graveolens triggers apoptosis and autophagy in skin melanoma cells: a novel apoptosis-independent autophagic signaling pathway. Phytother Res. 2014;28(8):1153-1162. doi:10.1002/ptr.5107 |