| Description | Lusianthridin is a natural product from Dendrobium venustum. Lusianthridin exhibits anti-migratory property at nontoxic concentrations. Lusianthridin enhances c-Myc degradation through the inhibition of Src-STAT3 signaling. |
| In vitro | Lusianthridin 对人类肺癌细胞系显示出明显的细胞毒性，其 IC50 值为 65.0 μg/mL [1]。在 H460 和 H292 细胞中，Lusianthridin (0-100 μM) 在超过 50 μM 的浓度下抑制了细胞活性 [2]。Lusianthridin 显著减少了 H460 和 H292 细胞中的 CSC 群体，并在 5、10 和 20 μM 的浓度下，分别使 H460 CSC 球体的大小在第三天大约减少了 10%、63% 和 77% [2]。 |
| molecular weight | 242.27 |
| Molecular formula | C15H14O3 |
| CAS | 87530-30-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Cytotoxic and Antimigratory Activities of Phenolic Compounds from Dendrobium brymerianum.Evid Based Complement Alternat Med. 2015;2015:350410. 2. Narumol Bhummaphan, et al. Targeting of Lung Cancer Stem Cells via Src-STAT3 Suppression. Phytomedicine. 2019 Sep;62:152932. |