| Description | Cholic acid sodium (SodiumCholate) exhibits a strong spermicidal and antiviral [anti-human immunodeficiency virus (HIV)-1] activity. |
| In vivo | Cholic acid (sodium cholate) exhibits a strong spermicidal and antiviral [anti-human immunodeficiency virus (HIV)-1] activity.?The same effects are observed for F-5 Gel, the active mixture of a new contraceptive sponge (Protectaid), which contains sodium cholate in association with low concentrations (0.5%) of nonoxynol-9 and benzalkonium chloride.?Both cholic acid and the F-5 Gel exert a dose-dependent, in-vitro inhibitory effect (i) on the activity of HIV-1 associated reverse transcriptase in an acellular system and (ii) on the potential of HIV-1 efficiently to infect human lymphocytes. |
| Synonyms | 胆酸钠, [胆酸钠], SodiumCholate |
| molecular weight | 430.55 |
| Molecular formula | C24H39NaO5 |
| CAS | 361-09-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 15 mg/mL (34.84 mM), Sonication is recommended. |
| References | 1. Psychoyos A , Creatsas G , Hassan E , et al. Spermicidal and antiviral properties of cholic acid: contraceptive efficacy of a new vaginal sponge (ProtectaidR) containing sodium cholate[J]. Human Reproduction(6):6. |