| Description | Buspirone (Buspirone free base) is an azaspiro compound which has a role as an anxiolytic drug, a sedative, a serotonergic agonist and an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor. |
| Synonyms | Buspirone free base, Ansial, 丁螺环酮 |
| molecular weight | 385.5 |
| Molecular formula | C21H31N5O2 |
| CAS | 36505-84-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 5.63 mg/mL (14.59 mM), Sonication is recommended. |
| References | 1. Torrisi SA, et al. Buspirone Counteracts MK-801-Induced Schizophrenia-Like Phenotypes through Dopamine D(3) Receptor Blockade. Front Pharmacol. 2017 Oct 4;8:710. 2. Reynolds AR, et al. Buspirone maintenance does not alter the reinforcing, subjective, and cardiovascular effects of intranasal methamphetamine. Drug Alcohol Depend. 2017 Dec 1;181:25-29. 3. Di Ciano P, et al. The effects of buspirone on occupancy of dopamine receptors and the rat gambling task. Psychopharmacology (Berl). 2017 Nov;234(22):3309-3320. 4. Santa Cruz MR, et al. Buspirone for the treatment of dementia with behavioral disturbance. Int Psychogeriatr. 2017 May;29(5):859-862. |