| Description | 3-O-Methylgalangin (GALANGIN-3-METHYLETHER) has antibacterial activity, it has inhibitory effects on Pseudomonas aeruginosa. GALANGIN-3-METHYLETHER has hypolipidemic activity, the action is due to the inhibition of pancreatic lipase. |
| In vitro | GALANGIN-3-METHYLETHER markedly reduced the viability of Leishmania amastigotes. |
| Cell experiments | L. amazonensis amastigotes were maintained and cultured axenically .Washed parasites were resuspended in RPMI-1640 medium supplemented with 4% fetal calf serum, pH 5.0, and incubated at 33 C for 18 h with crude extracts (1 mg/mL) or isolated compounds(GALANGIN-3-METHYLETHER) (0.014, 0.084, 0.5, and 1.0 mg/mL) dissolved in dimethyl sulfoxide (DMSO)/RPMI-1640 (1:99).?The amastigote viability was assessed colorimetrically by the reduction of a tetrazolium salt (MTT) as.?Absorbances were expressed as percentages relative to untreated controls.?Amphotericin B (0.02 mg/mL) was used as the positive control and DMSO/RPMI-1640 (1:99) as negative control.?The bioassays were carried out in triplicate. |
| Synonyms | 3-Methylgalangin, GALANGIN-3-METHYLETHER, 高良姜素 3-O-甲醚, 高良姜素-3-甲醚 |
| molecular weight | 284.26 |
| Molecular formula | C16H12O5 |
| CAS | 6665-74-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 25 mg/mL (87.95 mM) |
| References | 1. Salvador, Marcos José, Sartori F T , Sacilotto A C B C , et al. Bioactivity of Flavonoids Isolated from Lychnophora markgravii against Leishmania amazonensis Amastigotes[J]. Zeitschrift für Naturforschung C, 2009, 64(7-8). |