| Description | (2S)-2'-Methoxykurarinone is isolated from the roots of Sophora flavescens. (2S)-2'-Methoxykurarinone has anti-inflammatory, antipyretic, antidiabetic, and antineoplastic effects. (2S)-2'-Methoxykurarinone inhibits osteoclastogenesis and bone resorption through down-regulation of RANKL signaling. (2S)-2'-Methoxykurarinone displays cytotoxic activity against human myeloid leukemia HL-60 cells. |
| In vitro | 2'-Methoxykurarinone has strong alpha-glucosidase inhibitory activities, with IC(50) values of 155 microM. 2'-Methoxykurarinone is a noncompetitive inhibitor of protein tyrosine phosphatase 1B. |
| Synonyms | 2'-甲氧基苦参黄素, 2'-Methoxykurarinone, 2'-O-Methylkurarinone |
| molecular weight | 452.54 |
| Molecular formula | C27H32O6 |
| CAS | 270249-38-2 |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 24 mg/mL (53.03 mM) |
| References | 1. Sasaki T, et al. Protein tyrosine phosphatase 1B inhibitory activity of lavandulyl flavonoids from roots of Sophora flavescens. Planta Med. 2014 May;80(7):557-60. 2. Kim JY, et al. (2S)-2'-Methoxykurarinone inhibits osteoclastogenesis and bone resorption through down-regulation of RANKL signaling. Biol Pharm Bull. 2014;37(2):255-61. 3. Kang TH, et al. Cytotoxic lavandulyl flavanones from Sophora flavescens. J Nat Prod. 2000 May;63(5):680-1. |