| Description | Ceanothic acid derivatives show cytotoxic effect against OVCAR-3 and HeLa cancer cell lines. |
| In vitro | Six ceanothane and 1-norceanothane derivatives (1, 2, 8-11) were prepared from Ceanothic acid dibenzyl ester. These ring-A homologues of betulinic acid exhibited cytotoxic effects. Among these, 1-decarboxy-3-oxo-Ceanothic acid (2) was found to be the most cytotoxic against OVCAR-3 and HeLa cancer cell lines, with an IC50 of 2.8 and 6.6 microg/mL, respectively, and an IC50 of 11.3 microg/mL against normal cell line FS-5. |
| molecular weight | 486.693 |
| Molecular formula | C30H46O5 |
| CAS | 21302-79-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Preparation and cytotoxic effect of ceanothic acid derivatives.J Nat Prod. 1998 Nov;61(11):1343-7. |