| Bioactivity | ω-Conotoxin Bu8 is a ω-conotoxin, which consists of 25 amino acid residues and three disulfide bridges. ω-Conotoxin Bu8 selectively and potently inhibits depolarization-activated Ba2+ currents mediated by rat CaV2.2 expressed in HEK293T cells (IC50= 89 nM)[1]. |
| Name | ω-Conotoxin Bu8 |
| Sequence | Cys-Lys-Arg-Lys-Gly-Ser-Ser-Cys-Arg-Arg-Thr-Ser-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Asn-Gly-Lys-Cys-NH2 (Disulfide bridge: Cys1-Cys16,Cys8-Cys20,Cys15-Cys25) |
| Shortening | CKRKGSSCRRTSYDCCTGSCRNGKC-NH2 (Disulfide bridge: Cys1-Cys16,Cys8-Cys20,Cys15-Cys25) |
| Formula | C103H174N42O35S6 |
| Molar Mass | 2753.13 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jinqin Chen, et al. A novel ω-conotoxin Bu8 inhibiting N-type voltage-gated calcium channels displays potent analgesic activity. Acta Pharm Sin B. 2021 Sep;11(9):2685-2693. |