σ1 Receptor antagonist 4_product_DataBase

Bioactivity	σ1 Receptor antagonist 4 (compound TC1) is a selective sigma1 (σ1) receptor antagonist with a Ki of 10 nM. σ1 Receptor antagonist 4 is weakly active at σ2 receptor (Ki of 370 nM) and has no activity at dopamine (DAT), serotonin (SERT), and norepinephrine (NET) transporters[1].
In Vivo	σ1 Receptor antagonist 4（compound TC1; 3-100 mg/kg; 腹腔注射，单次）可减弱 20 mg/kg 可卡因的刺激性运动效应，半数最大抑制活性 (ID50) 为 38.6 mg/kg[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	362512-81-0
Formula	C19H20FNO
Molar Mass	297.37
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Xiang Liu, et al. Trishomocubanes: novel sigma ligands modulate cocaine-induced behavioural effects. Eur J Pharmacol. 2007 Jan 19;555(1):37-42.

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