| Bioactivity | κM-Conotoxin RIIIJ (κM-RIIIJ) is a selective Kv1.2 inhibitor with an IC50 of 33 nM[1]. |
| Target | IC50: 33 nM (human Kv1.2 channel) |
| Name | κM-Conotoxin RIIIJ |
| Sequence | Leu-{Hyp}-{Hyp}-Cys-Cys-Thr-{Hyp}-{Hyp}-Lys-Lys-His-Cys-{Hyp}-Ala-{Hyp}-Ala-Cys-Lys-Tyr-Lys-{Hyp}-Cys-Cys-Lys-Ser (Disulfide bridge:Cys4-Cys17, Cys5-Cys22, Cys12-Cys23) |
| Shortening | L-{Hyp}-{Hyp}-CCT-{Hyp}-{Hyp}-KKHC-{Hyp}-A-{Hyp}-ACKYK-{Hyp}-CCKS (Disulfide bridge:Cys4-Cys17, Cys5-Cys22, Cys12-Cys23) |
| Formula | C117H184N32O36S6 |
| Molar Mass | 2807.30 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chen P, et al. Biochemical characterization of kappaM-RIIIJ, a Kv1.2 channel blocker: evaluation of cardioprotective effects of kappaM-conotoxins. J Biol Chem. 2010 May 14;285(20):14882-14889. |