| Bioactivity | γ-secretase-IN-2 (Compound 36) is an inhibitor for γ-secretase, with an IC50 of 0.07 nM[1]. |
| Target | IC50: 0.07 nM (γ-secretase) |
| CAS | 564462-36-8 |
| Formula | C31H24F3N3O3 |
| Molar Mass | 543.54 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Churcher I, et al., Design and synthesis of highly potent benzodiazepine gamma-secretase inhibitors: preparation of (2S,3R)-3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]-diazepin-3-yl)butyramide by use of an asymmetric Ireland-Claisen rearrangement. J Med Chem. 2003 Jun 5;46(12):2275-8. |