| Bioactivity | γ-Secretase modulator 12 (Compound 1a) is a γ-secretase modulator that can selectively decrease amyloid-β42 (Aβ42) levels (IC50 of 0.39 µM). γ-Secretase modulator 12 can be used for Alzheimer’s disease research. γ-Secretase modulator 12 has a good brain/plasma ratio (Kp, brain = 0.72) in mice[1]. |
| Name | γ-Secretase modulator 12 |
| CAS | 2204249-82-9 |
| Formula | C25H23N3O2 |
| Molar Mass | 397.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ryuichi Sekioka, et al. Discovery of N-ethylpyridine-2-carboxamide derivatives as a novel scaffold for orally active γ-secretase modulators. Bioorg Med Chem. 2020 Jan 1;28(1):115132. |
γ-Secretase modulator 12
CAS: 2204249-82-9 F: C25H23N3O2 W: 397.47
γ-Secretase modulator 12 (Compound 1a) is a γ-secretase modulator that can selectively decrease amyloid-β42 (Aβ42) l
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