| Bioactivity | 5-{8-[(3,4'- difluoro [1,1'- biphenyl]-4-yl) methoxy] - 2-methylimidazo [1,2-a] pyridin-3-yl}-n-methylpyridin-2-formamide (1o) showed high potency in vitro and brain exposure, inducing brain a β 42 levels were significantly reduced and showed undetectable inhibition of cytochrome P450 enzymes. In addition, compound 1o showed excellent anti cognitive deficit effect in AD model mice. |
| Name | γ-Secretase modulator 11 |
| CAS | 2434630-29-0 |
| Formula | C28H22F2N4O2 |
| Molar Mass | 484.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sekioka R,et al. Optimization and biological evaluation of imidazopyridine derivatives as a novel scaffold for γ-secretase modulators with oral efficacy against cognitive deficits in Alzheimer's disease model mice. Bioorg Med Chem. 2020 Jun 1;28(11):11545 |
γ-Secretase modulator 11
CAS: 2434630-29-0 F: C28H22F2N4O2 W: 484.50
5-{8--4-yl) methoxy] - 2-methylimidazopyridin-3-yl}-n-methylpyridin-2-formamide (1o) showed high potency in vitro and br
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