| Bioactivity | γ-Secretase modulator 11 hydrochloride (compound 1o) is a potent and orally active γ-secretase modulator with an IC50 of 0.029 µM. γ-Secretase modulator 11 hydrochloride induces a robust reduction in brain Aβ42 levels. γ-Secretase modulator 11 hydrochloride rescues cognitive deficits exhibited by AD model mice. γ-Secretase modulator 11 hydrochloride has the potential for the research of alzheimer's disease[1]. |
| Target | IC50: 0.029 µM nM (γ-Secretase) |
| Name | γ-Secretase modulator 11 hydrochloride |
| CAS | 2434630-30-3 |
| Formula | C28H23ClF2N4O2 |
| Molar Mass | 520.96 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sekioka R, et al. Optimization and biological evaluation of imidazopyridine derivatives as a novel scaffold for γ-secretase modulators with oral efficacy against cognitive deficits in Alzheimer's disease model mice. Bioorg Med Chem. 2020 Jun 1;28(11):1154 |
γ-Secretase modulator 11 hydrochloride
CAS: 2434630-30-3 F: C28H23ClF2N4O2 W: 520.96
γ-Secretase modulator 11 hydrochloride (compound 1o) is a potent and orally active γ-secretase modulator with an IC50
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