| Bioactivity | β3-AR agonist 2 is a potent and selective β3-adrenergic receptor (β3-AR) agonist with an EC50 of 8 nM. |
| Target | EC50: 8 nM (β3-adrenergic receptor) |
| Invitro | β3-AR agonist 2 (Compound 26e) is found to be potent and selective at the β3 receptor, nearly completely abolishes intrinsic activity at either the β1 or β2 receptor[1]. |
| In Vivo | β3-AR agonist 2 (Compound 26e) has significant thermogenesis effects on human β3-adrenergic receptor transgenic mice. β3-AR agonist 2 acts as a potential drug for the treatment of human obesity and type II diabetes[1]. |
| Name | β3-AR agonist 2 |
| CAS | 340757-05-3 |
| Formula | C27H38N4O7S |
| Molar Mass | 562.68 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hu B, et al. (4-Piperidin-1-yl)phenyl amides: potent and selective human beta(3) agonists. J Med Chem. 2001 Apr 26;44(9):1456-66. |