| Bioactivity | β2AR/M-receptor agonist-2 (compound 15) is a muscarinic antagonist and β2 adrenoceptor agonist (MABA). β2AR/M-receptor agonist-2 shows potency to β2 adrenoceptor with an EC50 value of 3.7 nM. β2AR/M-receptor agonist-2 also has potency to human cloned M3 receptor with a Ki value of 0.73 nM. β2AR/M-receptor agonist-2 is a potent bronchodilator, it can be used for the research of chronic obstructive pulmonary disease (COPD)[1]. |
| In Vivo | β2AR/M-receptor agonist-2 剂量依赖地抑制甲基胆碱诱导的犬支气管收缩，其 ID50 值为 50 mg[1]。 |
| Name | β2AR/M-receptor agonist-2 |
| CAS | 1017857-38-3 |
| Formula | C36H49ClN4O7S |
| Molar Mass | 717.31 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Laura Hilton, et al. Optimized glucuronidation of dual pharmacology β-2 agonists/M3 antagonists for the treatment of COPD. MedChemComm. 2011. |
β2AR/M-receptor agonist-2
CAS: 1017857-38-3 F: C36H49ClN4O7S W: 717.31
β2AR/M-receptor agonist-2 (compound 15) is a muscarinic antagonist and β2 adrenoceptor agonist (MABA). β2AR/M-recepto
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