| Bioactivity | β-catenin-IN-8 (Compound 25) is a β-catenin inhibitor. β-catenin-IN-8 inhibits β-catenin and c-Myc protein levels, and inhibits Wnt-target genes level (Fgf20 and Sall4). β-catenin-IN-8 has colorectal cancer anticancer activities, and has metabolic stability[1]. |
| Invitro | β-catenin-IN-8 inhibits the growth of SW480 and HCT116 cancer cells with IC50s of 2 and 0.12 μM respectively[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> β-catenin-IN-8 相关抗体: |
| CAS | 259130-14-8 |
| Formula | C15H12ClN3O2S |
| Molar Mass | 333.79 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Puxeddu M, et al. Development of N-(4-(1H-Imidazol-1-yl)phenyl)-4-chlorobenzenesulfonamide, a Novel Potent Inhibitor of β-Catenin with Enhanced Antitumor Activity and Metabolic Stability. J Med Chem. 2024 Nov 28;67(22):20298-20314. |
β-catenin-IN-8
CAS: 259130-14-8 F: C15H12ClN3O2S W: 333.79
β-catenin-IN-8 (Compound 25) is a β-catenin inhibitor. β-catenin-IN-8 inhibits β-catenin and c-Myc protein levels, a
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