| Bioactivity | β-Amyrone (β-Amyron) is a triterpene compound which has anti-inflammatory activity through inhibiting the expression of COX-2. β-Amyrone has antifungal activity , as well as antiviral activity against Chikungunya virus. β-Amyrone also inhibits α-glucosidase and acetylcholinesterase (AChE) activity. β-Amyrone can be used in the research of disease like inflammation, infection, and obesity[1][2][3][4]. |
| Invitro | β-Amyrone (1.25-10 μg/mL, 24 h) inhibits on NO∙ production in LPS-stimulated J774 cells, with an IC50 value of 4.61 μg/mL, and has no obvious effect on cell viability[1].β-Amyrone (10 μg/mL, 24 h) inhibits IL-6, IL-10 levels, and COX-2 expression in LPS-stimulated J774 cells[1].β-Amyrone (0-235 μM, 7days) has antiviral activity in Vero cells against Chikungunya virus (CHIKV), with EC50 value of 86 uM[2].β-Amyrone inhibits α-glucosidase, acetylcholinesterase (AChE) and fungal activity with IC50 values of 25 μM, 23 μM and 8 μg/mL, respectively[4]. Western Blot Analysis[1] Cell Line: |
| In Vivo | β-Amyrone (local administration on ear, 0.1-0.6 mg/kg, a single dose) inhibits ear edema formation in phenol-induced edema mice[1]. Animal Model: |
| Name | β-Amyrone |
| CAS | 638-97-1 |
| Formula | C30H48O |
| Molar Mass | 424.70 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| Reference | [1]. Patrícia D O de Almeida, et al. Anti-Inflammatory Activity of Triterpenes Isolated from Protium paniculatum Oil-Resins. Evid Based Complement Alternat Med. 2015;2015:293768. [2]. Mélanie Bourjot, et al. Chemical constituents of Anacolosa pervilleana and their antiviral activities. Fitoterapia. 2012 Sep;83(6):1076-80. [3]. Ki-Kwang Oh, et al. Elucidating Drug-Like Compounds and Potential Mechanisms of Corn Silk ( Stigma Maydis) against Obesity: A Network Pharmacology Study. Curr Issues Mol Biol. 2021 Nov 6;43(3):1906-1936. [4]. Ata A, et al. Chemical constituents of Drypetes gossweileri and their enzyme inhibitory and anti-fungal activities. Phytochemistry Letters, 2011, 4(1): 34-37. |