αvβ5 integrin-IN-2_product_DataBase

Bioactivity	αvβ5 integrin-IN-2 (Cpd_AV2) is an αvβ5 integrin inhibitor that disrupts the stability of integrin heterodimers. αvβ5 integrin-IN-2 targets the β-propeller central pocket of ITGAV (integrin αV). αvβ5 integrin-IN-2 induces cellular apoptosis[1].
Invitro	αvβ5 integrin-IN-2 (Cpd_AV2) 可减少细胞表面整合素 αVβ5 的存在，IC50 约为 6.9 μM[1]。αvβ5 integrin-IN-2 (Cpd_AV2; 40 µM; 0-3 h) 在处理后 3 小时内导致明显的细胞凋亡和细胞周期停滞[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> αvβ5 integrin-IN-2 相关抗体: Apoptosis Analysis[1] Cell Line:
CAS	1005104-60-8
Formula	C32H40N4
Molar Mass	480.69
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Nicole M Mattson, et al. A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens. Nat Struct Mol Biol. 2024 Feb 5.

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