| Bioactivity | αvβ1 integrin-IN-1 (Compound C8) is a potent and selective αvβ1 integrin inhibitor with an IC50 of 0.63 nM. Antifibrotic effects[1]. |
| Target | IC50: 0.63 nM (αvβ1 integrin) |
| Invitro | αvβ1 integrin-IN-1 (Compound C8) significantly reduces the fibrotic markers in mouse model for liver and lung fibrosis[1]. |
| Name | αvβ1 integrin-IN-1 |
| CAS | 1689540-62-2 |
| Formula | C26H34N6O6S |
| Molar Mass | 558.65 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Reed NI, et al. Exploring N-Arylsulfonyl-l-proline Scaffold as a Platform for Potent and Selective αvβ1 Integrin Inhibitors. ACS Med Chem Lett. 2016 Aug 30;7(10):902-907. |
αvβ1 integrin-IN-1
CAS: 1689540-62-2 F: C26H34N6O6S W: 558.65
αvβ1 integrin-IN-1 (Compound C8) is a potent and selective αvβ1 integrin inhibitor with an IC50 of 0.63 nM. Antifibr
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