| Bioactivity | αC-Conotoxin PrXA is a paralytic peptide neurotoxin and a competitive nAChR antagonist, with IC50s of 1.8 nM (α1β1εδ, adult) and 3.0 nM (α1β1γδ, fetal), respectively. αC-Conotoxin PrXA competes with α-bungarotoxin at the α/δ and α/γ subunit interfaces of the nAChR, shows high specificity against neuromuscular nAChR[1]. |
| Target | IC50: 1.8 nM (α1β1εδ, adult) and 3.0 nM (α1β1γδ, fetal) |
| Name | αC-Conotoxin PrXA |
| Sequence | Thr-Tyr-Gly-Ile-Tyr-Asp-Ala-Lys-Pro-{Hyp}-Phe-Ser-Cys-Ala-Gly-Leu-Arg-Gly-Gly-Cys-Val-Leu-Pro-{Hyp}-Asn-Leu-Arg-{Hyp}-Lys-Phe-Lys-Glu-NH2 (Disulfide bridge: Cys13-Cys20) |
| Shortening | TYGIYDAKP-{Hyp}-FSCAGLRGGCVLP-{Hyp}-NLR-{Hyp}-KFKE-NH2 (Disulfide bridge: Cys13-Cys20) |
| Formula | C160H247N43O44S2 |
| Molar Mass | 3541.06 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jimenez EC, et al. AlphaC-conotoxin PrXA: a new family of nicotinic acetylcholine receptor antagonists. Biochemistry. 2007 Jul 31;46(30):8717-24. |