| Bioactivity | α5IA (L-822179) is a selective α5 GABAA receptor inverse agonist with neuroprotective potential[1]. |
| Invitro | α5IA (100 nM, 5 days) 可以使小鼠原代海马培养物中 Aβ 1-42 诱导的细胞死亡显着减少[1]。 Cell Viability Assay[1] Cell Line: |
| In Vivo | α5IA (5 mg/kg, i.p., once) 可持续恢复 Ts65Dn 小鼠的空间学习能力，以及长期识别的空间记忆缺陷[2]。 |
| Name | α5IA |
| CAS | 215874-86-5 |
| Formula | C17H14N8O2 |
| Molar Mass | 362.35 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chitra Vinnakota, et al. An 5 GABAA Receptor Inverse Agonist, 5IA, Attenuates Amyloid Beta-Induced Neuronal Death in Mouse Hippocampal Cultures. Int J Mol Sci. 2020 May 6;21(9):3284. [2]. Arnaud Duchon, et al. Long-lasting correction of in vivo LTP and cognitive deficits of mice modelling Down syndrome with an α5-selective GABAA inverse agonist. Br J Pharmacol. 2020 Mar;177(5):1106-1118. |