| Bioactivity | α-Synuclein inhibitor 8 is an active inhibitor of α-Synuclein with an IC50 value of 2.5 µM. α-Synuclein inhibitor 8 has highly inhibition on the aggregation and disaggregation of α-Synuclein fibers. α-Synuclein inhibitor 8 reduces the formation of inclusions in neurons that can repairs damage neurons and improves Parkinson’s disease (PD)-like symptoms. α-Synuclein inhibitor 8 has high antioxidant activity and low cytotoxicity[1]. |
| Target | IC50: 2.5 µM |
| Invitro | α-Synuclein inhibitor 8 (Compound 2ee) (0-100 μM；0-96 h) 以剂量依赖的方式抑制 α-Synuclein 的聚集[1]。α-Synuclein inhibitor 8 (100 µM；48 h) 将成熟的纤维分解成可溶性蛋白质及少量的短的不溶性纤维[1]。α-Synuclein inhibitor 8 (1-1000 µM；0.5 h 或 24 h) 以剂量依赖的方式增加活性氧的清除率。α-Synuclein inhibitor 8 对 H4 和 SH-SY5Y 细胞毒性低 (细胞活力高于 80 %)[1]。α-Synuclein inhibitor 8 (10 µM；38 h) 对 H4 细胞内 α-Synuclein 聚集和包涵体形成有抑制作用[1]。 Cell Viability Assay[1] Cell Line: |
| In Vivo | α-Synuclein inhibitor 8 (Compound 2ee) (0.9 μg/μL；静脉注射；单剂量) 显著改善帕金森病 C57 小鼠模型的抓力减弱、四肢僵硬和平衡不良等帕金森 (PD) 样症状。α-Synuclein inhibitor 8 对帕金森病 C57 小鼠模型的大脑中尾壳核 (CPu) 和黑质网状部 (SNr) 具有神经保护作用[1]。 Animal Model: |
| Name | α-Synuclein inhibitor 8 |
| Formula | C22H20N2O6 |
| Molar Mass | 408.40 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lü MH, et al. Hybrids of polyphenolic/quinone acids, the potential preventive and therapeutic drugs for PD: Disaggregate α-Syn fibrils, inhibit inclusions, and repair damaged neurons in mice. Eur J Med Chem. 2023 Jan 18;249:115122. |