| Bioactivity | α-Hemolysin (Staphylococcus aureus) is one of the most characteristic virulence factors secreted by Staphylococcus aureus, a polypeptide capable of destroying the host cell plasma membrane. After α-Hemolysin binds to the cell surface, its monomers assemble into a homoheptamer to form a front pore, which then transforms into a mature transmembrane pore water channel, allowing K+ and Ca2+ ion transport, leading to necrotic death of target cells[1]. |
| Invitro | α-Hemolysin (Staphylococcus aureus) 在 THP-1 细胞中可诱导 IL-1β 分泌和 caspase-1 激活，且是通过 NLRP3-炎性体依赖性 caspase-1 的激活诱导 IL-1β 分泌[1]。 α-Hemolysin (Staphylococcus aureus)(1 µg/mL, 4h) 可以诱导 THP 衍生细胞死亡，需要宿主 NLRP3 信号传导，但不依赖于 caspase-1 激活和 IL-1β 分泌[1]。 |
| Name | α-Hemolysin (Staphylococcus aureus) |
| CAS | 94716-94-6 |
| Sequence | Ala-Asp-Ser-Asp-Ile-Asn-Ile-Lys-Thr-Gly-Thr-Thr-Asp-Ile-Gly-Ser-Asn-Thr-Thr-Val-Lys-Thr-Gly-Asp-Leu-Val-Thr-Tyr-Asp-Lys-Glu-Asn-Gly-Met-His-Lys-Lys-Val-Phe-Tyr-Ser-Phe-Ile-Asp-Asp-Lys-Asn-Ala-Ile-Lys-Lys-Leu-Leu-Val-Ile-Arg-Thr-Lys-Gly-Thr-Ile-Ala-Gly-Gln-Tyr-Arg-Val-Tyr-Ser-Glu-Glu-Gly-Ala-Asn-Lys-Ser-Gly-Leu-Ala-Trp-Pro-Ser-Ala-Phe-Lys-Val-Gln-Leu-Gln-Leu-Pro-Asp-Asn-Glu-Val-Ala-Glu-Ile-Ser-Asp-Tyr-Tyr-Pro-Arg-Asn-Ser-Ile-Asp-Thr-Lys-Glu-Tyr-Met-Ser-Thr-Leu-Thr-Tyr-Gly-Phe-Asn-Gly-Asn-Val-Thr-Gly-Asp-Asp-Thr-Gly-Lys-Ile-Gly-Gly-Leu-Ile-Gly-Ala-Asn-Val-Ser-Ile-Gly-His-Thr-Leu-Lys-Tyr-Val-Gln-Pro-Asp-Phe-Lys-Thr-Ile-Leu-Glu-Ser-Pro-Thr-Asp-Lys-Lys-Val-Gly-Trp-Lys-Val-Ile-Phe-Asn-Asn-Met-Val-Asn-Gln-Asn-Trp-Gly-Pro-Tyr-Asp-Arg-Asp-Ser-Trp-Asn-Pro-Val-Tyr-Gly-Asn-Gln-Leu-Phe-Met-Lys-Thr-Arg-Asn-Gly-Ser-Met-Lys-Ala-Ala-Asp-Asn-Phe-Leu-Asp-Pro-Asn-Lys-Ala-Ser-Ser-Leu-Leu-Ser-Ser-Gly-Phe-Ser-Pro-Asp-Phe-Ala-Thr-Val-Ile-Thr-Met-Asp-Arg-Lys-Ala-Ser-Lys-Gln-Gln-Thr-Asn-Ile-Asp-Val-Ile-Tyr-Glu-Arg-Val-Arg-Asp-Asp-Tyr-Gln-Leu-His-Trp-Thr-Ser-Thr-Asn-Trp-Lys-Gly-Thr-Asn-Thr-Lys-Asp-Lys-Trp-Thr-Asp-Arg-Ser-Ser-Glu-Arg-Tyr-Lys-Ile-Asp-Trp-Glu-Lys-Glu-Glu-Met-Thr-Asn |
| Shortening | ADSDINIKTGTTDIGSNTTVKTGDLVTYDKENGMHKKVFYSFIDDKNAIKKLLVIRTKGTIAGQYRVYSEEGANKSGLAWPSAFKVQLQLPDNEVAEISDYYPRNSIDTKEYMSTLTYGFNGNVTGDDTGKIGGLIGANVSIGHTLKYVQPDFKTILESPTDKKVGWKVIFNNMVNQNWGPYDRDSWNPVYGNQLFMKTRNGSMKAADNFLDPNKASSLLSSGFSPDFATVITMDRKASKQQTNIDVIYERVRDDYQLHWTSTNWKGTNTKDKWTDRSSERYKIDWEKEEMTN |
| Formula | C1269H1971N339O400S6 |
| Molar Mass | 28569.06 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
α-Hemolysin (Staphylococcus aureus)
CAS: 94716-94-6 F: C1269H1971N339O400S6 W: 28569.06
α-Hemolysin (Staphylococcus aureus) is one of the most characteristic virulence factors secreted by Staphylococcus aure
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