α-Glucosidase-IN-63_product_DataBase

Bioactivity	α-Glucosidase-IN-63 (Compound 4d) is an inhibitor of α-Glucosidase (IC50=0.44 μM). α-Glucosidase-IN-63 inhibits hCA II with an activity of Ki= 7.0 nM. α-Glucosidase-IN-63 is orally effective.[1].
Invitro	α-Glucosidase-IN-63 抑制人碳酸酐酶 (hCA) 的能力分别为 Ki=7.0 nM (hCA II), 19.9 nM (hCA XII), 64.1 nM (hCA IX)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> α-Glucosidase-IN-63 相关抗体:
In Vivo	α-Glucosidase-IN-63 (p.o.) 在 Streptozocin (HY-13753) 诱导的糖尿病小鼠中显示出显著的降血糖效果,葡萄糖耐量明显恢复,效果优于标准药物 Acarbose (HY-B0089)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	2375866-82-1
Formula	C16H12FN3O3S2
Molar Mass	377.41
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Gamal MA, et al. Probing benzenesulfonamide-thiazolidinone hybrids as multitarget directed ligands for efficient control of type 2 diabetes mellitus through targeting the enzymes: α-glucosidase and carbonic anhydrase II. Eur J Med Chem. 2024 May 5;271:116434.

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