| Bioactivity | α-Glucosidase-IN-55 (Compound 8g) is an orally active and competitive alpha-glucosidase inhibitor, with IC50 and Ki values of 12.1 and 9.66 µM, respectively. α-Glucosidase-IN-55 can be used for the research into type 2 diabetes mellitus (T2DM) to improve blood sugar control and metabolic health[1]. |
| In Vivo | α-Glucosidase-IN-55 (2-8 mg/kg，口服，每日一次，28 天) 可显著降低糖尿病大鼠的空腹血糖 (FBG) 水平[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Formula | C31H22ClN3S |
| Molar Mass | 504.04 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Azmi A, et al. Alpha-glucosidase inhibitory and hypoglycemic effects of imidazole-bearing thioquinoline derivatives with different substituents: In silico, in vitro, and in vivo evaluations. Bioorg Chem. 2024 Mar;144:107106. |