| Bioactivity | α-Glucosidase-IN-23 is an orally active α-Glucosidase inhibitor. α-Glucosidase-IN-23 decreases blood glucose by a-glucosidase inhibition with an IC50 value of 4.48 μM. α-Glucosidase-IN-23 can be used for the research of diabetes[1]. |
| Target | IC50: 4.48 μM (a-glucosidase). |
| Invitro | α-Glucosidase-IN-23 (compound 8b) (1 μM) 具有显著的抗糖尿病作用[1]。α-Glucosidase-IN-23 减少 β 细胞和肌肉细胞中的 ROS[1]。α-Glucosidase-IN-23 通过抑制 a-glucosidase 降低血糖，IC50 值为 4.48 μM[1]。 Cell Proliferation Assay[1] Cell Line: |
| In Vivo | α-Glucosidase-IN-23（口服；0.2 mmol/kg/天）仅抑制小鼠体内的 α-葡萄糖苷酶[1]。 Animal Model: |
| Name | α-Glucosidase-IN-23 |
| CAS | 161187-57-1 |
| Formula | C20H23NO6 |
| Molar Mass | 373.40 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Peter A Sidhom, et al. Mechanistic Insight of Synthesized 1,4-Dihydropyridines as an Antidiabetic Sword against Reactive Oxygen Species. J Med Chem. 2023 Jan 12;66(1):991-1010. |
α-Glucosidase-IN-23
CAS: 161187-57-1 F: C20H23NO6 W: 373.40
α-Glucosidase-IN-23 is an orally active α-Glucosidase inhibitor. α-Glucosidase-IN-23 decreases blood glucose by a-glu
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