| Bioactivity | α-Glucosidase-IN-20 (Compound 3B) is a potent, orally active α-glucosidase inhibitor with an IC50 of 3.01 μM. α-Glucosidase-IN-20 shows anti-diabetic activity[1]. |
| In Vivo | α-Glucosidase-IN-20 (Compound 3B; 10 and 20 mg/kg; p.o.; daily, for 4 weeks) has anti-diabetic activity in Streptozocin (HY-13753)-induced diabetic rats[1].α-Glucosidase-IN-20 (10 and 20 mg/kg; p.o.; once) significantly decreases the serum glucose level after the administration of glucose (3 g/kg, oral) in rats[1].α-Glucosidase-IN-20 (2000 mg/kg; p.o.; daily, for 2 weeks) demonstrates no mortality in mice[1]. Animal Model: |
| Name | α-Glucosidase-IN-20 |
| CAS | 420809-56-9 |
| Formula | C23H21NOS |
| Molar Mass | 359.48 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mehmood R, et al. Synthesis of Novel 2, 3-Dihydro-1, 5-Benzothiazepines as α-Glucosidase Inhibitors: In Vitro, In Vivo, Kinetic, SAR, Molecular Docking, and QSAR Studies. ACS Omega, 2022 Aug 17. |
α-Glucosidase-IN-20
CAS: 420809-56-9 F: C23H21NOS W: 359.48
α-Glucosidase-IN-20 (Compound 3B) is a potent, orally active α-glucosidase inhibitor with an IC50 of 3.01 μM. α-Gluc
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