α-Glucosidase-IN-17_product_DataBase

Bioactivity	α-Glucosidase-IN-17 (Compound 12B) is a potent, orally active α-glucosidase inhibitor with an IC50 of 3.79 μM. α-Glucosidase-IN-17 shows antidiabetic activity[1].
Target	IC50: 3.79 μM (α-glucosidase)
In Vivo	α-Glucosidase-IN-17 (Compound 12B) (10 and 20 mg/kg; p.o.; b.w. for 4 weeks) shows antidiabetic activity in Streptozocin (HY-13753)-induced diabetic rats[1].α-Glucosidase-IN-17 (10 and 20 mg/kg; p.o.; once) significantly decreases the serum glucose level after the administration of glucose (3 g/kg, oral) in rats[1].α-Glucosidase-IN-17 (2000mg/kg; p.o.; b.w. for 2 weeks) demonstrates no mortality in mice[1]. Animal Model:
Name	α-Glucosidase-IN-17
CAS	2820424-84-6
Formula	C30H27NO2S
Molar Mass	465.61
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Mehmood R, et al. Synthesis of Novel 2, 3-Dihydro-1, 5-Benzothiazepines as α-Glucosidase Inhibitors: In Vitro, In Vivo, Kinetic, SAR, Molecular Docking, and QSAR Studies. ACS Omega, 2022.

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