α-Glucosidase-IN-11_product_DataBase

Bioactivity	α-Glucosidase-IN-11 is a highly permeable competitive α-glucosidase inhibitor with the IC50 value of 0.56 μM. α-Glucosidase-IN-11 binds to Trp residues in α-glucosidase and regulates protein folding. α-Glucosidase-IN-11 can be used to regulate blood glucose levels[1].
Invitro	α-Glucosidase-IN-11 (compound 3k) inhibits α-glucosidase, α-fucosidase and α-mannosidase with the IC50 value of 0.56 μM, 30.4 μM and 41.2 μM, respectively[1].α-Glucosidase-IN-11 (compound 3k) ( 0.1-100 μM, 24 hours) can induce β-cell proliferation at lower concentration[1]. Cell Proliferation Assay[1] Cell Line:
In Vivo	α-Glucosidase-IN-11 (compound 3k) (gastric gavage, 60 mg/kg, everyday, 4 weeks) can improve blood glucose levels during fasting[1]. Animal Model:
Name	α-Glucosidase-IN-11
CAS	2411744-76-6
Formula	C23H20N2O6
Molar Mass	420.41
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Tania Luthra, et al. Discovery of novel pyrido-pyrrolidine hybrid compounds as alpha-glucosidase inhibitors and alternative agent for control of type 1 diabetes. Eur J Med Chem. 2020 Feb 15;188:112034.

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