| Bioactivity | α-Conotoxin TxID is a potent α3β4 nAChR antagonist with an IC50 value of 12.5 nM. α-Conotoxin TxID has weak inhibition activity of closely related α6/α3β4 nAChR (IC50= 94 nM). α-Conotoxin TxID has the potential for novel smoking cessation drug development[1]. |
| Target | IC50: α3β4 nAChR |
| Name | α-Conotoxin TxID |
| CAS | 1496617-64-1 |
| Sequence | Gly-Cys-Cys-Ser-His-Pro-Val-Cys-Ser-Ala-Met-Ser-Pro-Ile-Cys-NH2 (disulfide bridge:Cys2-Cys8,Cys3-Cys15) |
| Shortening | GCCSHPVCSAMSPIC-NH2 (disulfide bridge:Cys2-Cys8,Cys3-Cys15) |
| Formula | C58H92N18O18S5 |
| Molar Mass | 1489.79 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Xiaodan Li, et al. α-Conotoxin TxID and [S9K]TxID, α3β4 nAChR Antagonists, Attenuate Expression and Reinstatement of Nicotine-Induced Conditioned Place Preference in Mice. . Mar Drugs. 2020 Dec 16;18(12):646. doi: 10.3390/md18120646. |
α-Conotoxin TxID
CAS: 1496617-64-1 F: C58H92N18O18S5 W: 1489.79
α-Conotoxin TxID is a potent α3β4 nAChR antagonist with an IC50 value of 12.5 nM. α-Conotoxin TxID has weak inhibiti
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