| Bioactivity | α-Conotoxin GIC is a potent and selective α3β2 nicotinic antagonist with an IC50 of 1.1 nM[1]. |
| Target | IC50: 1.1 nM (hα3β2), 309 nM (hα4β2), 755 nM (hα3β4), >100,000 nM (hα1β1δ?) |
| Name | α-Conotoxin GIC |
| CAS | 757236-92-3 |
| Sequence | Gly-Cys-Cys-Ser-His-Pro-Ala-Cys-Ala-Gly-Asn-Asn-Gln-His-Ile-Cys-NH2 (Disulfide bridge:Cys2-Cys8;Cys3-Cys16) |
| Shortening | GCCSHPACAGNNQHIC-NH2 (Disulfide bridge:Cys2-Cys8;Cys3-Cys16) |
| Formula | C61H92N24O20S4 |
| Molar Mass | 1609.79 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. McIntosh JM, et al. Alpha-conotoxin GIC from Conus geographus, a novel peptide antagonist of nicotinic acetylcholine receptors. J Biol Chem. 2002 Sep 13;277(37):33610-5. |