| Bioactivity | α-Conotoxin EIIB (Alpha-conotoxin EIIB) is a toxin peptide that can be obtained from Conus ermineus. α-Conotoxin EIIB binds to nAChR (Ki=2.2 nM). α-Conotoxin EIIB can be used in the study of neurological diseases such as schizophrenia, drug addiction, Alzheimer's disease, and Parkinson's disease[1]. |
| Name | α-Conotoxin EIIB |
| Sequence | {Pyr}-Thr-{Hyp}-Gly-Cys-Cys-Trp-His-Pro-Ala-Cys-Gly-Lys-Asn-Arg-Cys-NH2 (Disulfide bridge:Cys5-Cys11, Cys6-Cys16) |
| Shortening | {Pyr}-T-{Hyp}-GCCWHPACGKNRC-NH2 (Disulfide bridge:Cys5-Cys11, Cys6-Cys16) |
| Formula | C71H103N25O20S4 |
| Molar Mass | 1754.99 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Echterbille J, et al. Discovery and characterization of EIIB, a new α-conotoxin from Conus ermineus venom by nAChRs affinity capture monitored by MALDI-TOF/TOF mass spectrometry. Toxicon. 2017 May;130:1-10. |