α-Conotoxin BuIA_product_DataBase

Bioactivity	α-Conotoxin BuIA is a paralytic peptide neurotoxin and a competitive nAChR antagonist, with IC50s of 0.258 nM (α6/α3β2), 1.54 nM (α6/α3β4), 5.72 nM (α3β2), respectively. α-Conotoxin BuIA can be used to distinguish nAChRs containing β2- and β4-subunit, respectively. α-Conotoxin BuIA distinguishes among αxβ2 nAChRs with a rank order potency of α6>α3>α2>α4[1].
Target	IC50: 0.258 nM (α6/α3β2), 1.54 nM (α6/α3β4), 5.72 nM (α3β2)
Name	α-Conotoxin BuIA
CAS	846539-62-6
Sequence	Gly-Cys-Cys-Ser-Thr-Pro-Pro-Cys-Ala-Val-Leu-Tyr-Cys-NH2 (Disulfide bridge: Cys2-Cys8, Cys3-Cys13)
Shortening	GCCSTPPCAVLYC-NH2 (Disulfide bridge: Cys2-Cys8, Cys3-Cys13)
Formula	C54H82N14O16S4
Molar Mass	1311.57
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Azam L, et al. Alpha-conotoxin BuIA, a novel peptide from Conus bullatus, distinguishes among neuronal nicotinic acetylcholine receptors. J Biol Chem. 2005 Jan 7;280(1):80-7.

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