| Bioactivity | α-Conotoxin AuIB TFA, a potent and selective α3β4 nicotinic acetylcholine receptor (nAChR) antagonist, blocks α3β4 nAChRs expressed in Xenopus oocytes with an IC50 of 0.75 μM[1]. | ||||||
| Invitro | α-Conotoxin AuIB blocks the α3β4 receptor with >100-fold higher potency than other receptor subunit combinations, including α2β2, α2β4, α3β2, α4β2, α4β4, and α1β1γδ[1]. | ||||||
| Name | α-Conotoxin AuIB TFA | ||||||
| Sequence | Gly-Cys-Cys-Ser-Tyr-Pro-Pro-Cys-Phe-Ala-Thr-Asn-Pro-Asp-Cys-NH2 (Disulfide bridge:Cys2-Cys8;Cys3-Cys15) | ||||||
| Shortening | GCCSYPPCFATNPDC-NH2 (Disulfide bridge:Cys2-Cys8;Cys3-Cys15) | ||||||
| Formula | C67H90F3N17O23S4 | ||||||
| Molar Mass | 1686.78 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
α-Conotoxin AuIB TFA
CAS: F: C67H90F3N17O23S4 W: 1686.78
α-Conotoxin AuIB TFA, a potent and selective α3β4 nicotinic acetylcholine receptor (nAChR) antagonist, blocks α3β4
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