| Bioactivity | μ-Conotoxin KIIIA TFA is an analgesic μ-conotoxin that can be isolated from Conus kinoshitai. μ-Conotoxin KIIIA blocks mammalian neuronal voltage-gated sodium channels (VGSCs) (Nav1.2). μ-Conotoxin KIIIA TFA can be used for research of pain[1][2]. |
| Sequence | Cys-Cys-Asn-Cys-Ser-Ser-Lys-Trp-Cys-Arg-Asp-His-Ser-Arg-Cys-Cys-NH2 (Disulfide bonds: Cys1-Cys9,Cys2-Cys15,Cys4-Cys16) |
| Shortening | CCNCSSKWCRDHSRCC-NH2 (Disulfide bonds: Cys1-Cys9,Cys2-Cys15,Cys4-Cys16) |
| Formula | C70H106N28O22S6.xC2HF3O2 |
| Molar Mass | 1884.16 (free base) |
| Appearance | 固体 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Khoo KK,et al. Structure of the analgesic mu-conotoxin KIIIA and effects on the structure and function of disulfide deletion. Biochemistry. 2009 Feb 17;48(6):1210-9. [2]. Pan X, Li Z, et al. Molecular basis for pore blockade of human Na+ channel Nav1.2 by the μ-conotoxin KIIIA. Science. 2019 Mar 22;363(6433):1309-1313. |
µ-Conotoxin KIIIA TFA
CAS: F: C70H106N28O22S6.xC2HF3O2 W: 1884.16 (free base)
μ-Conotoxin KIIIA TFA is an analgesic μ-conotoxin that can be isolated from Conus kinoshitai. μ-Conotoxin KIIIA block
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