yGsy2p-IN-1_product_DataBase

Bioactivity

yGsy2p-IN-1 is a potent inhibitor for yeast glycogen synthase 2 (yGsy2p). yGsy2p-IN-1 is a competitive human glycogen synthase 1 (hGYS1) inhibitor with an IC50 of 2.75 µM and a Ki of 1.31 µM for wild-type hGYS1. yGsy2p-IN-H23 a pyrazole inhibitor, is used for glycogen storage diseases (GSDs)[1].

Target

IC50: 2.75 µM (hGYS1)Ki: 1.31 µM (wild-type hGYS1)

Invitro

yGsy2p-IN-1 (compound 23; 0.1, 1, 10, 100, 1000 µM) has IC50s of 7.89 μM and 33.6 μM for yGsy2p-WT and yGsy2p-Y513L[1]. yGsy2p-IN-1 (100 μM) exhibits almost complete inhibition of synthase activity in both HEK293-PTG and Rat-1 cell lysates[1].

Name

yGsy2p-IN-1

CAS

2415003-97-1

Formula

C16H11F3N2O4

Molar Mass

352.26

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Buyun Tang, et al. Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase. J Med Chem. 2020 Apr 9;63(7):3538-3551.

PeptideDB

yGsy2p-IN-1

CAS: 2415003-97-1 F: C16H11F3N2O4 W: 352.26