| Bioactivity | xStAx-VHLL is a PROTAC β-catenin degrader that manifests strong inhibition of Wnt signaling and sustains degradation of β-catenin in cancer cells and the intestinal organoids derived from wild-type and APC–/– mice. xStAx-VHLL can be used as a promising anticancer agent[1]. |
| Name | xStAx-VHLL |
| Sequence | Ac-Arg-Arg-Trp-Pro-Arg-{X}-Ile-Leu-Asp-{X}-His-Val-Arg-Arg-Val-Trp-Arg-{Ahx}-Ala-Leu-Ala-Pro-Tyr-Ile-Pro-NH2 (X-6 and X-10 stapled together with a double bond) |
| Shortening | Ac-RRWPR{X}ILD{X}HVRRVWR-{Ahx}-ALAPYIP-NH2 (X-6 and X-10 stapled together with a double bond) |
| Formula | C154H244N48O29 |
| Molar Mass | 3231.89 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Liao H, et al. A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer. Cell Discov. 2020 Jun 9;6:35. |