| Bioactivity | Trans-Cevimeline (AF102A) (hydrochloride), as a trans-isomer of AF102B, is a M1 selective cholinergic agonist. Trans-Cevimeline (AF102A) (hydrochloride) can be used for the research of Alzheimer's disease[1]. |
| Target | M1 |
| In Vivo | AF102A (1 mg/kg; i.p.) reverses cognitive impairments in a step-through passive avoidance task[1]. Animal Model: |
| Name | trans-Cevimeline hydrochloride |
| CAS | 107220-29-1 |
| Formula | C10H18ClNOS |
| Molar Mass | 235.77 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Fisher A, et al. (+-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3')quinuclidine, an M1 selective cholinergic agonist, attenuates cognitive dysfunctions in an animal model of Alzheimer's disease. J Pharmacol Exp Ther. 1991;257(1):392-403. |
trans-Cevimeline hydrochloride
CAS: 107220-29-1 F: C10H18ClNOS W: 235.77
Trans-Cevimeline (AF102A) (hydrochloride), as a trans-isomer of AF102B, is a M1 selective cholinergic agonist. Trans-Cev
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