st-Ht31_product_DataBase

Bioactivity	st-Ht31 is a membrane-permeable peptide inhibitor of protein kinase A (PKA) anchoring. st-Ht31 induces robust cholesterol/phospholipid efflux. st-Ht31 completely reverses foam cell formation and restores the metabolic health of macrophage[1][2].
Invitro	st-Ht31 (5 µM; 2 h) 增强 BHK 细胞和 RAW 巨噬细胞中的胆固醇/磷脂流出[1]。st-Ht31 (10µM; 24 h) 逆转泡沫细胞形成并恢复巨噬细胞的代谢健康[1]。st-Ht31 (20 µM; 20 min) 消除 HEK293T 细胞中 PMA 诱导的 ERK1/2 激活的 cAMP 抑制[2]。 Western Blot Analysis[2] Cell Line:
Name	st-Ht31
CAS	188425-80-1
Sequence	{N-Stearate}-Leu-Ile-Glu-Glu-Ala-Ala-Ser-Arg-Ile-Val-Asp-Ala-Val-Ile-Glu-Gln-Val-Lys-Ala-Ala-Gly-Ala-Tyr
Shortening	{N-Stearate}-LIEEAASRIVDAVIEQVKAAGAY
Formula	C129H217N29O39
Molar Mass	2798.32
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Ma L, et al. Ht31, a protein kinase A anchoring inhibitor, induces robust cholesterol efflux and reverses macrophage foam cell formation through ATP-binding cassette transporter A1. J Biol Chem. 2011 Feb 4;286(5):3370-8. [2]. Rahamim Ben-Navi L, et al. A-Kinase Anchoring Protein 4 (AKAP4) is an ERK1/2 substrate and a switch molecule between cAMP/PKA and PKC/ERK1/2 in human spermatozoa. Sci Rep. 2016 Nov 30;6:37922.

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