st-Ht31 ammonium

CAS: F: C129H217N29O39.xNH3 W: 2798.32 (free base)

st-Ht31 ammonium is a membrane-permeable peptide inhibitor of protein kinase A (PKA) anchoring. st-Ht31 ammonium induce

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Bioactivity	st-Ht31 ammonium is a membrane-permeable peptide inhibitor of protein kinase A (PKA) anchoring. st-Ht31 ammonium induces robust cholesterol/phospholipid efflux. st-Ht31 ammonium completely reverses foam cell formation and restores the metabolic health of macrophage[1][2].
Invitro	st-Ht31 (5 µM; 2 h) ammonium enhances cholesterol/phospholipid efflux in BHK cells and RAW macrophages[1].st-Ht31 (10µM; 24 h) ammonium reverses foam cell formation and restores metabolic health of macrophage[1].st-Ht31 (20 µM; 20 min) ammonium abolishes the cAMP inhibition of PMA-induced ERK1/2 activation n HEK293T cells[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> st-Ht31 ammonium 相关抗体:
Sequence	{N-Stearate}-Asp-Leu-Ile-Glu-Glu-Ala-Ala-Ser-Arg-Ile-Val-Asp-Ala-Val-Ile-Glu-Gln-Val-Lys-Ala-Ala-Gly-Ala-Tyr
Shortening	{N-Stearate}-DLIEEAASRIVDAVIEQVKAAGAY
Formula	C129H217N29O39.xNH3
Molar Mass	2798.32 (free base)
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Ma L, et al. Ht31, a protein kinase A anchoring inhibitor, induces robust cholesterol efflux and reverses macrophage foam cell formation through ATP-binding cassette transporter A1. J Biol Chem. 2011 Feb 4;286(5):3370-8. [2]. Rahamim Ben-Navi L, et al. A-Kinase Anchoring Protein 4 (AKAP4) is an ERK1/2 substrate and a switch molecule between cAMP/PKA and PKC/ERK1/2 in human spermatozoa. Sci Rep. 2016 Nov 30;6:37922.