| Bioactivity | sPLA2-IIA Inhibitor is a cyclic pentapeptide analog of FLSYK (cyclic 2-Nal-Leu-Ser-2-Nal-Arg (c2)), that binds to hGIIA (human IIA phospholipase A2) and inhibits its hydrolytic ability. sPLA2 is a member of the esterase superfamily that catalyzes the hydrolysis of the ester bond at the sn-2 position of glycerophospholipids, releasing free fatty acids such as arachidonic acid and lysophospholipids[1]. |
| Name | sPLA2-IIA Inhibitor |
| CAS | 236394-37-9 |
| Sequence | Cyclo({Nal}-Leu-Ser-{Nal}-Arg) |
| Shortening | Cyclo({Nal}-LS-{Nal}-R) |
| Formula | C41H50N8O6 |
| Molar Mass | 750.89 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kim RR, et al. Molecular dynamics simulations reveal structural insights into inhibitor binding modes and functionality in human Group IIA phospholipase A2. Proteins. 2017;85(5):827-842. doi:10.1002/prot.25235 |
sPLA2-IIA Inhibitor
CAS: 236394-37-9 F: C41H50N8O6 W: 750.89
sPLA2-IIA Inhibitor is a cyclic pentapeptide analog of FLSYK (cyclic 2-Nal-Leu-Ser-2-Nal-Arg (c2)), that binds to hGIIA
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