| Bioactivity | sEH/HDAC6-IN-2 is a potent dual soluble epoxide hydrolase (sEH) and HDAC6 inhibitor with IC50s of 0.9 nM, 46.8 nM, and 8 nM for human sEH, mouse sEH, and HDAC6, respectively. sEH/HDAC6-IN-2 can be used for the study of inflammatory pain[1]. |
| Invitro | sEH/HDAC6-IN-2 对 HDAC6 的抑制活性具有明显的选择性（选择性指数：HDAC1/HDAC6 = 144，HDAC2/HDAC6 = 62，HDAC3/HDAC6 = 160，HDAC8/HDAC6 = 8，HDAC11/HDAC6 = 58）[1]。sEH/HDAC6-IN-2（化合物 28g；1-2 μM；24 小时）诱导 α-微管蛋白乙酰化增加，而不影响组蛋白 H3，表明选择性抑制 HDAC6[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> sEH/HDAC6-IN-2 相关抗体: Western Blot Analysis[1] Cell Line: |
| In Vivo | sEH/HDAC6-IN-2（compound 28g；30 mg/kg; 腹腔注射；一次）缓解小鼠福尔马林引起的炎症疼痛[1]。静脉和口服给药后 SD 大鼠中 sEH/HDAC6-IN-2 的药代动力学[1]。1.19 parameter |
| CAS | 3009011-58-6 |
| Formula | C27H32ClF2N5O5 |
| Molar Mass | 580.02 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Huashen Xu , et al. Design and Synthesis of sEH/HDAC6 Dual-Targeting Inhibitors for the Treatment of Inflammatory Pain. J Med Chem. 2024 Jul 21. |
sEH/HDAC6-IN-2
CAS: 3009011-58-6 F: C27H32ClF2N5O5 W: 580.02
sEH/HDAC6-IN-2 is a potent dual soluble epoxide hydrolase (sEH) and HDAC6 inhibitor with IC50s of 0.9 nM, 46.8 nM, and 8
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