| Bioactivity | sEH inhibitor-9 (compound 21) is a sEH inhibitor with IC50 values of 0.4 and 0.5 nM for human sEH and murine sEH, respectively. sEH inhibitor-9 inhibits mechanical hypersensitivity and cystitis in mouse models. sEH inhibitor-9 can be used for the research of inflammation[1]. |
| Invitro | sEH inhibitor-9 (0-1 μM) inhibits human sEH and murine sEH with IC50 values of 0.4 and 0.5 nM, respectively[1].sEH inhibitor-9 (0-100 μM) shows inhibition to cytochrome with IC50 values of 30, 32 and 2 μM for CYP 2C9, CYP 2C19 and CYP 3A4, respectively[1]. |
| In Vivo | sEH inhibitor-9 (0.312-2.5 mg/kg; s.c. once) inhibits mechanical hypersensitivity and cystitis in vivo[1].1.19Pharmacokinetic Properties of sEH inhibitor-9 in Mice [1]. |
| Name | sEH inhibitor-9 |
| Formula | C27H36FN3O3 |
| Molar Mass | 469.59 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Codony S, et al. Synthesis, In Vitro Profiling, and In Vivo Evaluation of Benzohomoadamantane-Based Ureas for Visceral Pain: A New Indication for Soluble Epoxide Hydrolase Inhibitors. J Med Chem. 2022 Oct 27;65(20):13660-13680. |